Research

A lesser known work in Goya’s Black Paintings, focusing on the aging and death of a C. elegans nematode

Research Perspective

Our group studies the complex causal pathways through which diet, environment, and genetic factors interact to determine the nature and timing of bad outcomes in aging such as poor health and death.
To understand how changes in the molecular level alter the dynamics of aging at the organismal level, we develop and apply new, physics-inspired experimental methods and quantitative modelling approaches.

Methodologically, we apply a mix of molecular genetics including functional genomics, synthetic biology, CRISPR genome editing ( in particular, developing constructs that allow us to precisely modulate aging in vivo ),  high-throughput imaging, statistical and complex-systems modelling, and math.

Research Environment

Our group is a member of the Systems Biology programme at the Centre for Genomic Regulation (CRG), giving us excellent colleagues and access to all of the CRG’s world-class core facilities.

The city of Barcelona is a technical and biomedical hub with many research institutes, the IRB, the photonics institute, the Barcelona Supercomputing Center, as well as several universities including the UPF , UB, and the UAB and a small but lively biomedical startup ecosystem. Barcelona also has a thriving makers scene, which is great for the members of our group building custom high-throughput imaging apparatus.

The CRG itself occupies the fifth and sixth floors of the biomedical research building PRBB, located on the beach a short walk from the heart of downtown Barcelona.