2024-2023
Eder M, Martin O.M.F, Oswal N, Sedlackova L, Moutinho C, Del Carmen-Fabregat A, Menendez Bravo S, Sebé-Pedrós A, Heyn H, Stroustrup N. Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony. Cell (in press)
del Carmen Fabregat A, Sedlackova L, Oswal N, Stroustrup N. High-throughput Behavioral Aging and Lifespan Assays using the Lifespan Machine. Journal of Visual Experiments 203. (2024)
Nada Al-Refaie, Francesco Padovani, Francesca Binando, Johanna Hornung, Qiuxia Zhao, Benjamin D Towbin, Elif Sarinay Cenik, Nicholas Stroustrup, Kurt M Schmoller, Daphne Selvaggia Cabianca. An mTOR/RNA pol I axis shapes chromatin architecture in response to fasting. 2023 BioRxiv
2022-2020
Natasha Oswal, Olivier M.F. Martin, Sofia Stroustrup, Monika A.M. Bruckner, Stroustrup, N. A hierarchical process model links behavioral aging and lifespan in C. elegans. PLOS Computational Biology (18) 9 e1010415. (2022)
Cohen, Alan A; Ferrucci, Luigi; Fülöp, Tamàs; Gravel, Dominique; Hao, Nan; Kriete, Andres; Levine, Morgan E; Lipsitz, Lewis A; Olde Rikkert, Marcel GM; Rutenberg, Andrew, Stroustrup, N; Varadhan, Ravi. A complex systems approach to aging biology. Nature Aging 2 (7),580-591 (2022)
Cutler, Kevin J; Stringer, Carsen; Lo, Teresa W; Rappez, Luca; Stroustrup, N; Brook Peterson, S; Wiggins, Paul A; Mougous, Joseph D. Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation. Nature Methods 19 (11), 1438-1448 (2022)
Servello, Francesco A; Fernandes, Rute; Eder, Matthias; Harris, Nathan; Martin, Olivier MF; Oswal, Natasha; Lindberg, Anders; Derosiers, Nohelly; Sengupta, Piali; Stroustrup, N; Apfeld, Javier. Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature. Elife. 11 e78941 (2022)
Jodie A Schiffer, Francesco A Servello, William R Heath, Francis Raj Gandhi Amrit, Stephanie V Stumbur, Matthias Eder, Olivier MF Martin, Sean B Johnsen, Julian A Stanley, Hannah Tam, Sarah J Brennan, Natalie G McGowan, Abigail L Vogelaar, Yuyan Xu, William T Serkin, Arjumand Ghazi, Stroustrup, N, Javier Apfeld. Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies. Elife. 9:e56186. (2020)
2019-2018
Janssens, Georges E., Xin-Xuan Lin, Lluis Millan-Arino, Alan Kavšek, Ilke Sen, Renée I. Seinstra, Stroustrup, N, Ellen AA Nollen, and Christian G. Riedel. Transcriptomics-based screening identifies pharmacological inhibition of Hsp90 as a means to defer aging. Cell Reports 27, no. 2 467-480. (2019)
Stroustrup, N. Measuring and modeling interventions in aging. Curr. Opinion in Cell Biology, 55 (2018)
Lin X, Sen I, Janssens G, Zhou X, Fonslow B, Edgar D, Stroustrup N, Swoboda P,Yates J, Ruvkun G, Riedel C. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nature Communications 9 4400 (2018)
2017-2016
William B Zhang, Drew B Sinha, William E Pittman, Erik Hvatum, Stroustrup, N, Zachary Pincus. Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health. Cell Systems (2016) 333-345. e4
McEwan, Deborah L., Rhonda L. Feinbaum, Stroustrup, N, Wilhelm Haas, Annie L. Conery, Anthony Anselmo, Ruslan Sadreyev, Frederick M. Ausubel. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC biology (2016)
Select Previous Work
Stroustrup N, Anthony W, Nash Z.M, Gowda V, Gomez A, López-Moyado I.F, Apfeld J, Fontana W
The temporal scaling of C. elegans ageing. Nature, 530, 103-107 (2016)
Stroustrup N, Ulmschneider B. E. , Nash Z. M. , López Moyado I. F., Apfeld J, and Fontana W. The C. elegans Lifespan Machine. Nature Methods, 10, 665-670 (2013)
Fernandes de Abreu DA, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F, Cornils A, Regenass M, Neagu A, Ostojic I, Liu C, Cho Y, Sifoglu D, Shen Y, Fontana W, Lu H, Csikasz-Nagy A, Murphy CT, Antebi A, Blanc E, Apfeld J, Zhang Y, Alcedo J, Ch’ng Q. An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology. PLOS Genetics (2014)